Wavelength-Based Quantum Coding in Vision and Hearing: A Comparative Analysis of Neural Processing Architectures

¹Charitable Medical Organization, Mind-Body and Technology Research, Augusta, GA, USA

²Masters Student Northeastern University, Boston, MA, USA

*Corresponding author: Ravinder Jerath, Professor in the pain diploma program Central University of Venezuela

Hippocampal-Retinal Spatial Integration. The interaction between the visual system and the hippocampal spatial memory network is multifaceted. There exists a cortical link with the retina. Neurons within the primary visual cortex fire into a spatiotemporal locus; therefore, place cells within the hippocampus also fire along similar spatial pathways and temporally. Moreover, cells of V1 and CA1 are activated, concurrently, along discrete time intervals [4]. Therefore, spatial integration occurs, suggesting that the positioning of disc-like, photoreceptors serves as a framework for spatial orientation for constructing episodic memories dependent upon the hippocampus. Furthermore, default space posits that ~93% of retinal visual input occurs from cortical regions related to memory function, spatialization, and executive function—among others. This stimulation travels to the eyeball by lateral inhibition [10]. Thus top-down stimulation becomes a spatial reality that combines with bottom-up stimulation from the photoreceptors to create an edited version of what is seen, with depth effectively arranged along the layers of photoreceptor discs.

Coding principle convergence

Both systems rely on spatial coding: the quality of an input signal (wavelength/frequency) maps to a particular place within the cellular structure. For example, in the visual system, specific wavelengths of light preferentially activate certain opsins at specific layers of the discs due to stiffness and lengths of optical pathways. In addition, accommodation means that the focal length can change over time for mapping specific levels of the photoreceptor outer segment discs to prevent confusion when, for example, something may be present at two different depths. The necessity of stiffness in the visual system occurs because of wavelengths of light received. Photons interact with the morphology of the discs and spectral tuning of the opsins. This means shorter wavelengths (i.e. blue light) preferentially interact with discs with one geometric arrangement, while longer wavelengths (i.e. red light) are absorbed more significantly by stacks with another. This means that scientists can simultaneously map depth and color due to their arrangement within the visual system. The auditory system relies upon frequencies as well due to stiffness as relative widths of the basilar membrane. Stiffness manifests as specific widths and maximum displacements along the membrane: for example, 20 kHz has a maximum displacement along the stiff basal width (~0.1 mm), while 20 Hz has a maximum displacement along the more apical flexile width (~0.5 mm). Hair cell stereocilia throughout the auditory system preserve phase-locking relationships relative to acoustic stimulation which contribute to spatial frequency mapping and temporal coding mechanism.

Clinical pathology and disc disruption syndromes

Multiple disorders emphasize the relevance of proper disc and hair cell morphology for effective sensory functioning. For instance, retinitis pigmentosa (RP)—found in approximately 1 in 2000 individuals—is a degenerative disorder of photoreceptors over time and with abnormal morphological features that correlate with disc morphology [14]. RP1 mutations impact outer segment morphogenesis; thus, over time, these photoreceptors possess morphologically abnormal, shorter stacks of discs generating rhodopsin localization within the inner segments and cell bodies, in turn. Acute incessus of retinal inflammation results in abrupt vision loss with concomitant edema of the optic disc, indicating inflammatory properties associated with the disc's pathological components [22]. Moreover, outer segments possess unique regenerative capabilities; it's shown that when the outer segments were lost due to injury, one-to-one regeneration occurred where the outer segments were previously injured and lost during healing [22]. Hair cell loss is also the predominant feature involved with what we know of age-related hearing loss despite previously knowing that stria vascularis dysfunction was the cause of presbycusis [15]. For example, when evaluating sudden sensorineural hearing loss, one can determine age-related changes to hearing more accurately based on hair cell loss and degeneration than strial dysfunction; hair cell losses are a result of noise exposure, aging, ototoxic drugs, infections, and more drug therapies [7]. For example, in Peng's mechanistic studies, it was shown that both caspase-9 and caspase-3 mediate hair cell death; thus, their assessment for therapeutic targeting may allow for hair cell regeneration to occur [20].

Neurological accommodation disorders

Accommodation dysfunction also indicates certain aspects of the neural networks involved in spatial localization. For example, a common related condition to traumatic brain injury that attenuates the ability to accommodate involves the compromise of the diffuse connectivity required for accommodation in the occipital and parietal lobe, cerebellum, superior colliculus, and Edinger-Westphal nucleus [16]. Accommodative insufficiency relative to trauma occurs post-trauma as an accommodative test of symptoms shows findings far from age-adjusted expectations.

Accommodative-related neurological disorders include supranuclear lesions, encephalitis, tumors of the pinealis gland and neuromuscular disorders such as myasthenia gravis [23]. Light-near dissociation shows intact reflexes along one pathway while dysfunction along the other; therefore, neurosyphilis can accommodate but have intact light reflexes. Furthermore, the ability to accommodate is associated with the ciliary muscle-choroidal relationship—a tensional one—that renders the region of the optic nerve susceptible to glaucomatous damage via increase in pressure or tension [21].

Amplification Strategies and Quantum Limits

Both mechanisms implement active gains to overcome passive biological gains in sensitivity. The visual system relies upon a biochemical cascade to achieve this. The activation of one rhodopsin leads to the activation of one phosphodiesterase which alters the conformation of thousands of cGMPs. This biochemical gain of ~10⁶ enables the detection of a single photon and, under perfect conditions, quantum efficiency is close to 0.1. The auditory system relies on mechanical gain. Outer hair cell electromotility provides the active force. Cells with prestin change in length during depolarization/repolarization at sound frequencies up to 22 kHz, providing active, cycle-by-cycle mechanical gain to the motion of the basilar membrane. This process results in 40-60 dB increased sensitivity and 10-100 times increased frequency selectivity. While hair cell regeneration studies have been conducted in mice to understand the phenomenon, humans yield similar results; translational ramifications are on the cusp, as administered molecules that stimulate hair cell generation from supporting cells in the mouse model partially restore hearing sensitivity post noise trauma [7].

Integration with spatial memory networks

Both potential systems are highly connected to exogenously understood, spatiotemporally dispersed signals related to more complex networks. For instance, vision comes from multiple stacks of disc that integrate over time and compare frequencies to create color, depth and location; the ventromedial visual cortical "where" stream is comprised of projections from perihinal and V1 areas to retrosplenial and parahippocampal areas to entorhinal cortex and then hippocampus for scene processing [24]. Visual cortical neurons fire based upon location where one travels through space, and thus, hippocampal place cell firing is temporally and spatially relative to this activity [4]. Therefore, the relatively direct route from spatially driven visual sensation to development of a spatial memory suggests that the arrangement of photoreceptive discs serves as a fundamental mapping of coordinates to facilitate further navigation and episodic memory reliant upon the hippocampus. Likewise, hearing conforms to a temporal frequency detection via central auditory structures that receive information from tonotopically organized hair cells. The system of cochlear boosting results in sharp tuning along a frequency while also maintaining temporal fidelity necessary for locational sound detection and phonemic differentiation. For example, fibers of the auditory nerve phase-lock which supports explicit and clear temporal coding as well as its spatial frequency mapping of the cochlea.

Discussion

Therefore, the quasi-symmetrical architecture through quantum coding via wavelengths in vision and frequency-based coding in hearing demonstrates an important level of organizational similarities that suggests biological systems process these forms of information at a quantum level. Evolution has discovered convergent solutions for extracting the most information possible from wave-based input forms while operating sensitively at the most micro levels and entraining to spatially mapped memories. Quantum Mechanics and Spatial Mapping. It's not merely the case that we detect photons via absorption in vision or utilize derivational mechanical perturbations from sound waves in hearing. For instance, recent evidence shows that quantum coherence is involved in the remarkable functioning of both systems. In vision, for example, quantum-like coherence in rhodopsin photoisomerization is part of how fast and accurately the fundamental photochemical reaction goes [8].

Further, the organizational structure of the discs accomplishes more than color determinations via wavelength; it can also enact spatial distance coding via differences in focal lengths creating a three-dimensional structure that interdigitates naturally with hippocampal spatial processing centers. Default space suggests that coded depth is calibrated across ~ 1000 discs, with ~93% of all visual input coming from cortical spatial processing domains [10]. Thus, this top-down spatial organization incorporates ottom-up inputs from photoreceptors to make consistency as one coherent whole by which we can more easily navigate and structure memory.

In hearing, perhaps quantum mechanically, the mechanotransduction channels possess the extreme sensitivity and rapidity of hair cell responsiveness. For hair cells to undergo phase-locking capability, there exists the potential for precise temporal coding alongside a spatial frequency organizational system so that multidimensional acoustic frames come forth as sound scenes are processed. Disorder Treatment Potential and Pathological Disruption The importance of such narrative devices are crucial for treatment of sensory disorders and predicting functional projections. For example, retinal anomalies organize these findings into various types of retinal degeneration; RP1 mutations disrupt outer segment morphology and trafficking of rhodopsin [14]. Thus, through a progressive cumulative sense of such disc disruptions, one can imply projections based on where disruption occurs and at what time; focused interventions would do best to aim at disc integrity to maintain longevity of discourse.

Whereas with disruption relative to hair cell integrity penetrates the same for sensorineural hearing loss. Interventions focused on regenerative capabilities could render results for millions of persons with hearing deficits; it's hair cell degeneration, not strial death, that brings about presbycusis [15]. The ability for drugs to encourage supporting cell trans differentiation to hair cells shows proof-of-concept toward the ability [7]. Disorders of Accommodations within the Networks of Integration. The most neurological accommodations disorder shows just how far interdigitated the neural networks must be for spatially coded integration to occur. Accommodative abilities are remediated often through neurodegeneration from traumatic brain injuries; accommodation, convergence, and spatial orientation suffer as interconnected networks are disturbed [16]. Therefore, accommodation's relation to glaucoma indicates that accommodation stress may theoretically drive optic nerve degeneration via pressure and tension-induced mechanics [21].

Evolutionary optimization and spatial integration

The fact that these spatial organizations of coding converge at a quantum level infers they are the most effective solutions to very fundamental problems of information transduction. The ~1000 spacing of discs for photoreception and ~15,500 spacing for the hair cells of the cochlea operate nearly at their expected signal-to-noise-ratios within their range of operations yet are able to function at a quantum level of spatial coding.

The spatial codings of each imply optimization for different avenues of similar decoding as well as integration into higher dimensional memory. The discs are arranged in a compact vertical orientation to create the optimal surface area for light processing relative to distance coding via focus. The basilar membrane is elongated to span a great distance to allow for many hertz of frequency with tight frequency resolution abilities while allowing for strong duration coding via phase-locking. The projections between sensory output from visual cortical neurons to place cells in the hippocampus show this integration of sensory quantum coding and spatial memory systems [4]. Therefore, quantum coding of sensory experience provides fundamental spatial scaffolding for higher functioning such as navigation, episodic memory, and spatial awareness.

Implications for neural coding theory and technology

The similarities in coding schemes across modalities of sight and sound expose fundamental aspects of how information is processed by neurons at quantum levels. Where vision and audition are concerned, the spatially oriented nanostructures suggest that such processing capabilities operate at near fundamental physical limits while still engaging with higher-level cognitive networks. The success of such systems in reality suggests that the arrangement at quantum levels may be the universal trait across rapid, biological processing systems. Whether from a medical standpoint for better understanding of sensory systems gone awry or translation into biomimetic systems, this comparison yields much. For instance, a photoreceptor array could be artificially created from an understanding of the orientation of discs biologically for frequency-level sensitivity unknown to exist in low-light imaging settings, in conjunction with spatially coded capabilities. Likewise, a frequency analysis system could be created from an understanding of cochlea arrangements to foster faster processing systems or better speech-recognition programs with greater spatial awareness of auditory scenes.

Summary and Conclusions

This extensive comparative process suggests that wavelength-dependent quantum coding for vision and frequency-dependent coding for hearing is essentially analogous evolutionary solutions to fundamental processing issues. They both exist through a nanoscopic structural arrangement, quasi-stimulative qualities, and fancy compositional integrative abilities to yield insane degrees of sensitivity and distinction, all connected through a spatiotopic associative memory array.

The most important findings are:

• Structural/spatial convergence: Both systems evolve highly structured nano-scale arrays (~1000 discs in vision, ~15,500 hair cells/stereocilia in hearing) in respect to their input modality/spatial coding requirements.
• Coding strategy convergence: Spatially mapped recoding wavelengths (380-750 nm) and frequencies (20 Hz-20 kHz) permit the capacity to process the spectral/spatial components in parallel while distance recoding occurs through focal length variation in vision and temporal resolution/pitch differentiation through phase-locking in hearing.
• Similar amplification: Vision undergoes a biochemical cascade for amplification (10⁶-fold gain) while hearing possesses a mechanical amplification (4-60 dB gain), with both traits occurring at the near extreme/max threshold of each sense but simultaneously avoiding spatial coding distortions.
• Integrated memory systems: Both the visual/auditory systems integrate with the hippocampal spatial memory networks, as visual cortical neurons are functionally coupled with place cells and auditory integration contributes to the overall scene of spatiality.
• Pathophysiology syndromes: Disruption of the discs reflects syndromes/receptors of retinitis pigmentosa/preservative blinding in eye, similarly disruption of hair cells results in sensorineural hearing loss; both possess regenerative therapeutic approaches.
• Neurological networking integration: Sight accommodation defects suggest a compounded large network of required neural action suggestive of proper integration of spatial coding; relevant across studies and understandings of traumatic brain injury functionality/disruption and Alzheimer's Disease.
• Quantum efficiency: Both systems operate at quantum-limited potential via active mechanisms for amplification that supersedes passive limitations of physical nature yet allows for spatial coding.

Convergent evolution suggests that yet other information processing biological systems that operate at similarly high potentials may possess similar traits. The integration with spatial memory further indicates that sensory quantum networking also offers essential coordinates for higher-level thinking. Further studies should analyze whether such quantum networking akin to organizational capabilities/spatial coding is generalizable for neural systems functioning within such fundamental limits.

The translational potential is apparent for regenerative therapies as well as biomimetic sensing systems bilaterally structured at quantum-scale for optimal operating capabilities of spatially processing relevance. Future understanding of sensory system pathology, therapeutic/future interventions and biomimetic technology designed with these quantum biological blueprints will yield better performance in essentially anything that functions within spatial processing realms.

Figure 1: This diagram illustrates the wavelength-based quantum coding system in vision, showing the nano-architecture of approximately 1000 stacked membrane discs per cone photoreceptor. Each disc acts as a quantum register where wavelength-dependent resonance and disc geometry determine spectral encoding from 380-750 nm wavelengths.

Figure 2: This cross-section shows the frequency-based coding system in hearing, depicting the basilar membrane with its tonotopic organization of hair cells. The 35 mm basilar membrane length creates a macro-nano gradient where frequency-dependent resonance (20 Hz to 20 kHz) is spatially mapped through basilar membrane stiffness variations and stereocilia arrangement.

References

1. Baylor DA, Lamb TD, Yau KW. (1979) Responses of retinal rods to single photons. J Physiol. 288:613-34.
2. Dallos P, Evans BN. (1995) High-frequency motility of outer hair cells and the cochlear amplifier. Sci. 267(5206):2006-09.
3. Pöge M, Mahamid J, Inoue S, Palczewski K, Roux KJ, et al. (2021) Determinants shaping the nanoscale architecture of the mouse rod outer segment. eLife, 10, e72817.
4. Haggerty DC, Ji D. (2015) Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior. eLife. 4:e08902.
5. Rolls ET, Deco G, Huang CC, Feng J. (2022) The effective connectivity of the human hippocampal memory system. Cerebral Cortex. 32(17):3706-25.
6. Voldřich L. (1978). Mechanical properties of basilar membrane. Acta Otolaryngologica. 86(5-6):331-35.
7. Edge AS, Chen ZY, Liberman MC. (2024) Hair cell regeneration for treatment of sensorineural hearing loss. Nature Med. 30(2):393-405.
8. Chakravarthi R, Rajagopal AK, Devi ARU. (2008) Quantum mechanical basis of vision. arXiv
9. Fujihara-Mino A, Mitamura Y, Inomoto N. (2017) Optical coherence tomography parameters predictive of visual outcome after epiretinal membrane surgery. Retina. 37(4):673-79.
10. Jerath R, Beveridge C, Jensen M. (2018) Conceptual advances in the default space model of consciousness. World J Neurosci. 8(2):253-75.
11. Place R, Farovik A, Brockmann M, Eichenbaum H. (2022) Place cells dynamically refine grid cell activities to reduce error accumulation. Nature Commun. 13:7711.
12. Boccara CN, Nardin M, Stella F, O'Neill J, Csicsvari J. (2015) The entorhinal cognitive map is attracted to goals. Science. 347(6229):1443-46.
13. Recio-Spinoso A, Temchin AN, van Dijk P, Fan YH, Ruggero MA. (2017) On the tonotopy of the low-frequency region of the cochlea. J Neurophysiol. 118(3):1462-69.
14. Liu Q, Lyubarsky A, Skalet JH, Pugh Jr EN, Pierce EA. (2002) Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proceeding National Academy Sci. 99(8):5698-703.
15. Wu PZ, Liberman LD, Bennett K, de Gruttola V, O'Malley JT, et al. (2020) Age-related hearing loss is dominated by damage to inner ear sensory cells, not the cellular battery that powers them. J Neurosci. 40(33):6357-66.
16. Ciuffreda KJ, Singman EL, Douglas VP. (2015) Traumatic brain injury, visual consequences, and vision therapy. Optometry Vision Sci. 92(5):549-59.
17. Hallett PE. (1969) Quantum efficiency and false positive rate. Vision Res. 9(11):1292-94.
18. Gibson JJ. (1947) Motion picture testing and research. Report No. 7. AAF Aviation Psychology Program Research Reports.
19. Rolls ET, Wirth S, Deco G. (2023) The hippocampus, memory, and spatial function. Oxford Res Encyclopedia Psychol. 313-458.
20. Cheng AG, Cunningham LL, Rubel EW. (2005) Mechanisms of hair cell death and protection. Curr Opinion Otolaryngol Head Neck Surg. 13(6):343-48.
21. Kaufman PL, Bito LZ, DeRousseau CJ. (2018) The development of presbyopia in primates. Experimental Eye Res. 23(4):419-23.
22. Chandra P, Tripathy K, Chandra A. (2015) Acute unilateral vision loss with optic disc oedema in retinitis pigmentosa. BMJ Case Rep. bcr2015210931.
23. American Optometric Association. (2015) Care of the patient with accommodative and vergence dysfunction. Clinical Practice Guidelines.
24. Rolls ET, Huang CC, Lin CP, Feng J, Joliot M. (2024) A ventromedial visual cortical 'Where' stream to the human hippocampus for spatial scenes. Commun Bio. 7:1005.
25. Carroll J, Choi SS, Williams DR. (2015) Spontaneous regeneration of human photoreceptor outer segments. Sci Rep. 5:12364.