Research Article Aug 16,2026 Pedro Gutierrez-Castrellon¹⁵, Carolina Bluguermann², Ian Jenkins³, Krista Casazza⁴, Bradley Robinson⁵, Adrian Mutto², Jonathan R. T. Lakey³⁴⁵*

Chondrocyte and Mesenchymal Stem Cell–Based Regenerative Therapies for Osteoarthritis and Degenerative Bone Disorders

Background Osteoarthritis (OA) and related degenerative osteochondral disorders are driven by ..

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Research Article Aug 19,2026 Marcio Hiroaki Kume1*, Bianca Furlan2, Camila Gobatto Boaventura2, Mônica Andréa Probst2, Edson Peracchi2 and Carmen Austrália Paredes Marcondes Ribas3

Ultrasound-Guided Caudal Epidural Injections for Single-Level Lumbar Spinal Stenosis: A Randomised, Double-Blind Clinical Trial Comparing Platelet-Rich Plasma, Bone Marrow Aspirate, Corticosteroid and Combination Regenerative Therapies

Background: Epidural corticosteroid injection remains the most widely used interventional treatment ..

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Research Article Aug 21,2026 Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas3

Centrifugation Determines What Is in the Syringe, Not What Happens to the Patient: A Systematic Meta-Analysis of Platelet-Rich Plasma Preparation, Platelet Integrity, Cell Counts, Growth Factors and Clinical Outcomes in Regenerative Medicine

Background: Platelet-rich plasma (PRP) is prepared with centrifugation protocols that differ by ..

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Research Article Aug 23,2026 Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi² and Carmen Austrália Paredes Marcondes Ribas3

A Comprehensive Meta-Analysis of Orthobiologics in Arthrosis and Lumbar Degeneration: Moderate Symptomatic Benefit, Comparator-Dependent Effects and an Evidence-Tiered Framework for Clinical Practice

Background: Orthobiologic injections — platelet-rich plasma (PRP), bone marrow aspirate ..

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Research Article Aug 27,2026 Márcio Hiroaki Kume¹*, Bianca Furlan², Camila Gobatto Boaventura², Mônica Andréa Probst², Edson Peracchi², Carmen Austrália Paredes Marcondes Ribas3

A Three-Tier Framework for Orthobiologic Use in Arthrosis and Lumbar Degeneration: Separating What Is Proven Safe and Effective from What Is Merely Proven Safe

Background: Orthobiologic injections are offered to patients with arthrosis and degenerative lumbar ..

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Research Article Aug 28,2026 Marina Cordeiro MD1,2*

Beyond the Intervention: Biological Context as a Consideration in Regenerative Medicine

Background: Regenerative medicine has produced some of the most consequential therapeutic advances ..

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Mini Review Sep 10,2026 Miguel G Garber*

Biological Status before Biological Intervention: A Clinical Framework for Patient Evaluation Prior to Regenerative Longevity Therapies

Regenerative interventions should be preceded by a multidomain assessment of biological status, ..

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Review Article Sep 13,2026 Mike KS Chan1,2,3, Krista Casazza4, Michelle BF Wong1,2, Dmytro Klokol1,2, Nishkumay OI2,5 and Jonathan RT Lakey2,4*

Reconstructing Bone Repair: A Systems-Regeneration Framework Integrating Skeletal Precursor Cells, Mitochondrial Therapeutics, and Organ-Specific Peptide Signaling

Fracture healing is a highly coordinated regenerative process, yet delayed union and nonunion ..

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Latest Articles

Chondrocyte and Mesenchymal Stem Cell–Based Regenerative Therapies for Osteoarthritis and Degenerative Bone Disorders

Ultrasound-Guided Caudal Epidural Injections for Single-Level Lumbar Spinal Stenosis: A Randomised, Double-Blind Clinical Trial Comparing Platelet-Rich Plasma, Bone Marrow Aspirate, Corticosteroid and Combination Regenerative Therapies

Centrifugation Determines What Is in the Syringe, Not What Happens to the Patient: A Systematic Meta-Analysis of Platelet-Rich Plasma Preparation, Platelet Integrity, Cell Counts, Growth Factors and Clinical Outcomes in Regenerative Medicine

A Comprehensive Meta-Analysis of Orthobiologics in Arthrosis and Lumbar Degeneration: Moderate Symptomatic Benefit, Comparator-Dependent Effects and an Evidence-Tiered Framework for Clinical Practice

A Three-Tier Framework for Orthobiologic Use in Arthrosis and Lumbar Degeneration: Separating What Is Proven Safe and Effective from What Is Merely Proven Safe

Beyond the Intervention: Biological Context as a Consideration in Regenerative Medicine

Biological Status before Biological Intervention: A Clinical Framework for Patient Evaluation Prior to Regenerative Longevity Therapies

Reconstructing Bone Repair: A Systems-Regeneration Framework Integrating Skeletal Precursor Cells, Mitochondrial Therapeutics, and Organ-Specific Peptide Signaling

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