RS3PE Syndrome

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This article " RS3PE Syndrome- Orthobiological Therapy" was originally published in a special issue entitled “Role of regenerative medicine in orthopedics”, handled by Editor. Dr. Sharmila Tulpule.

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare rheumatologic disease of the elderly characterized by joint pain in the hands and wrists, with pitting edema and tenosynovitis of the tendinous structures of the wrist and hand and may, however, extend to other joint locations with a favorable response to glucocorticoids. We describe the case of a patient diagnosed with the RS3PE entity and followed up in a Physiatry consultation, in which a treatment with activated platelet-rich plasma according to the GOLDIC ® method was proposed, with very positive results that remained after 12 months of treatment.

 This therapeutic procedure produced a rapid improvement that was observed at the third injection and sustained in the symptomatology and resolution of the synovitis for one year to date. There were no treatment-related adverse events. The author declares that there are no conflicts of interest and the study was preceded by informed consent from the patient.

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