Recent published work on The Immunology Of Suicidal Behavior

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The oral cavity is an essential gateway to the human GI tract that affects the composition of the gut microbiome and by extension that of other organs. Several earlier studies have associated both the salivary and intestinal microbial communities with suicidal behavior, linking this pathology to the gene-microbiota interface. The translocation of microorganisms outside of the GI tract and the generation of antibodies to antigens mimicking neuronal proteins have been linked to suicidal behavior, connecting this pathology to immunity and autoimmunity. Moreover, as MHC genetics was associated with the risk of suicide as well as autoimmune diseases, in the near future, suicidal behavior may be reconceptualized as an infectious or immune, rather than psychiatric illness. Indeed, prior to the discovery of Helicobacter Pylori (H. Pylori), peptic ulcer disease was included among psychiatric disorders, setting a precedent for this type of pathogenetic shifts.

Altered human microbiome, the microbial community living in symbiosis with the host, was previously linked to suicidal behavior, suggesting that microbiota could be involved in this pathology. Indeed, the markers of bacterial translocation into the host circulatory system, including lipopolysaccharide (LPS) and intestinal fatty-acid binding protein (I-FABP), were reported to be elevated in individuals with recent suicide attempts, connecting this pathology with dysfunctional gut barrier. This is further substantiated by the earlier studies which reported increased suicide rates in patients with inflammatory bowel disease (IBS), further connecting microbial translocation outside the gastrointestinal (GI) tract with this behavior. 

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